Inhibitory Activity of Citrullus Colocynthis Extract on Native Leukemic Stem Cells
Keywords:
Citrullus colocynthis, leukemic stem cells, bone marrow, vencrstine, flowcytometry, lymphoid leukemia, myeloid leukemia, high bone marrow blast cellsAbstract
The failure of classical anti-leukemic drugs for treatment leukemia led to relapse. The majority of leukemic patients achieve complete remission after intensive chemotherapy, the majority relapse after 5 years and die of disease. Relapse still occurs in 80% of patients.
References
Attard, E. and Scicluna-Spiteri. (2001). Ecballium elaterium : an in vitro source of cucurbitacins Fitoterapia, 72: 46-53.
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3:730–7.
Bose, P., Vachhani, P. and Cortes JE (2017). Treatment of relapsed/refractory acute myeloid leukemia. Curr Treat Options Oncol 2017; 18: 17.
Boyum A. (1976). Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. Suppl. 5 9–15. Epub 1976/06/01. PubMed PMID: 1052391 10.1111/j.1365-3083.1976.tb03851.x
Costello, R. T. et al. (2000). Human acute myeloid leukemia CD34+/CD38- progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. /Cancer Res./ *60*, 4403–4411 .
Dean, M., Fojo, T. and Bates, S. (2005). Tumer stem cell and drug resistance. Nat. Rev. Cancer 5, 275-284. Doi: 10.1038/nrc1590.
De Rooij, J. D., Zwaan, C. M. & van den Heuvel-Eibrink, M. (2015). Pediatric AML: from biology to clinical management. /J. Clin. Med./ *4*, 127–149.
Dick, J. E. (2008). Stem cell concepts renew cancer research. /Blood/ *112*, 4793–4807 (2008).
Dohner, H. et al. (2010). Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. /Blood/ *115*, 453–474 .
Harbone, J.B. (1998). Phytochemical methods. Aqide to modern techniques of plant analysis. New York, U.S.A.Pp.54-150 .
Hussain A. I., Rathore H. A., Sattar M. Z., Chatha S. A., ud din Ahmad F., Ahmad A., et al. (2013). Phenolic profile and antioxidant activity of various extracts from Citrullus colocynthis (L.) from the Pakistani flora. Ind. Crops Prod. 45 416–422. 10.1016/j.indcrop.2013.01.002.
Ishikawa, F. et al. (2007) Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. /Nat. Biotechnol./ *25*, 1315–1321.
Marzouk B., Marzouk Z., Haloui E., Fenina N., Bouraoui A. and Aouni M. (2010). Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia. J. Ethnopharmacol. 128 15–19. 10.1016/j.jep.2009.11.027
Reya, T., Morrison S. J., Clarke M. F. and Weissman I. L. (2001). Stem cells, cancer, and cancer stem cells. Nature 414 105–111. 10.1038/35102167
Sabri N.N EL-Marsy. S., and Kafagy. S.M. (1973) Phytochemical investigation of Hyoscyamus desetorum, Planta Medica, 23:4-9.
Saito, Y. et al. (2010). Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. /Nat. Biotechnol./ *28*, 275–280.
Sawaya W. N., Daghir N. J., Khalil J. K. (1986). Citrullus colocynthis seeds as a potential source of protein for food and feed. J. Agric. Food Chem. 34 285–288. 10.1021/jf00068a035.
Shi C., Karim S., Wang C., Zhao M., Murtaza G. (2014). A review on antidiabetic activity of Citrullus colocynthis Schrad. Acta Pol. Pharm. 71 k363–367;
Tallman, M. S., Gilliland, D. G. and Rowe, J. M. (2005). Drug therapy for acute myedloid leukemia. /Blood/ *106*, 1154–1163.
Tannin-Spitz T., Grossman S., Dovrat S., Gottlieb H. E., Bergman M. (2007). Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochem. Pharmacol. 73 56–67. 10.1016/j.bcp.2006.09.012.
Vetrie, D., Helgason,G.V.,and Copland,M.(2020). The leukaemia stem cell:similarities, differences and clinical prospects in CML and AML.Nat.Rev.Cancer 20,158-173.doi:10.1038/s41568-091-0230-9.
Wang Y. Effect of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cell. Med. Chem.2011;106-111.
Zembruski N. C., Stache V., Haefeli W. E. & Weiss J. 7-Aminoactinomycin D for apoptosis staining in flow cytometry. Anal. Biochem. 429, 79–81 (2012). [PubMed] [Google Scholar].
